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  1. Post-exposure prophylaxis and pre-exposure prophylaxis are both highly effective options for HIV-negative people to reduce their risk of HIV infection. Lowering the viral load in the blood and rectal fluid through successful antiretroviral treatment eliminates the risk for sexual HIV transmission even when STIs are present. Condoms, in combination with lube, are highly effective in preventing the risk of HIV transmission if used consistently and correctly.

  2. Rectal fluid may not be the only fluid involved in the risk of HIV transmission during this type of sex. Minimizing rectal inflammation through the use of lubricants lubes and management of STIs regular STI testing and, if needed, treatment for STIs may prevent increases in rectal fluid viral load.

  3. In fact, the average risk of HIV infection through a single act of condomless insertive anal sex with an HIV-positive partner is slightly higher than through vaginal sex but much lower than if the HIV-negative person takes the receptive role during anal sex. Research show that this type of anal sex can carry a significant risk of HIV transmission.

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